≡

Acylglycerol Kinase (AGK)

[Edit]

MULK; Multiple Substrate Lipid Kinase

Acylglycerol Kinase (AGK)
CCC G236
HGNC 21869
MGI 1917173
PubMed 22284826
RGD 1562046
UniProt Q53H12
Wiki AGK
MULK contains an N-terminal diacylglycerol (DG) kinase domain, a putative nuclear localization signal, and a region with 44% homology to SPHK2. Comparison of putative vertebrate MULK orthologs showed strong conservation of amino acid sequences, and phylogenetic analysis of lipid kinases demonstrated that human and mouse Mulk together form a distinct lipid kinase family.
Expression of a MULK-EGFP fusion protein in 293T cells and CHO cells showed that MULK fractionates with membranes and localizes to internal membrane compartments. RT-PCR analysis showed MULK is ubiquitously expressed, with highest expression in pancreas and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG236Hu01 Recombinant Acylglycerol Kinase (AGK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG236Hu01 Polyclonal Antibody to Acylglycerol Kinase (AGK) WB; IHC; ICC; IP.
MAG236Hu21 Monoclonal Antibody to Acylglycerol Kinase (AGK) WB; IHC; ICC; IP.
Assay Kits SEG236Hu ELISA Kit for Acylglycerol Kinase (AGK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acylglycerol Kinase (AGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acylglycerol Kinase (AGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acylglycerol Kinase (AGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acylglycerol Kinase (AGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acylglycerol Kinase (AGK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acylglycerol Kinase (AGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acylglycerol Kinase (AGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acylglycerol Kinase (AGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acylglycerol Kinase (AGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acylglycerol Kinase (AGK) ELISA Kit Customized Service Offer
  1. "Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies."J. Lipid Res. 47:268-283(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells."J. Cell Biol. 169:801-811(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Lack of the mitochondrial protein acylglycerol kinase causes Sengers syndrome."Am. J. Hum. Genet. 90:314-320(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a truncation mutation of acylglycerol kinase (AGK) gene in a novel autosomal recessive cataract locus."Hum. Mutat. 33:960-962(2012) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing."Sci. Transl. Med. 4:118ra10-118ra10(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]