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Esterase D (ESD)

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FGH; S-formylglutathione hydrolase; Methylumbelliferyl-acetate deacetylase

Esterase D (ESD)
CCC G238
HGNC 3465
MGI 95421
PubMed 1886375
RGD 1592114
UniProt P10768
Wiki Esterase_D
ESD encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease.
Cowell et al. (1986) showed that there is a consistently lower level of esterase D enzyme activity in persons with the 2-2 phenotype when activity is measured in certain ways. They emphasized the importance of checking the electrophoretic phenotype before concluding that chromosome 13 deletion is present in a family being studied in connection with retinoblastoma (see later).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG238Hu01 Recombinant Esterase D (ESD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Esterase D (ESD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Esterase D (ESD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Esterase D (ESD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Esterase D (ESD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG238Mu01 Recombinant Esterase D (ESD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Esterase D (ESD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Esterase D (ESD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Esterase D (ESD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Esterase D (ESD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Esterase D (ESD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Esterase D (ESD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Esterase D (ESD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Esterase D (ESD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Esterase D (ESD) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma."Proc. Natl. Acad. Sci. U.S.A. 83:6337-6341(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma."Hum. Genet. 79:137-141(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAR-2007) to UniProtKB
  7. "Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13."Proc. Natl. Acad. Sci. U.S.A. 83:6573-6577(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Esterase D: a new human polymorphism."Ann. Hum. Genet. 37:119-137(1973) [PubMed] [Europe PMC] [Abstract]
  9. "Identity of the polymorphisms for esterase D and S-formylglutathione hydrolase in red blood cells."Hum. Genet. 74:174-175(1986) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human esterase D: a potential genetic marker of retinoblastoma."FASEB J. 23:1441-1446(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular analysis of esterase D polymorphism."Hum. Genet. 93:255-258(1994) [PubMed] [Europe PMC] [Abstract]
  15. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]