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Phosphoribosylformylglycinamidine Synthase (PFAS)

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PURL; FGARAT; FGAR Amidotransferase; Formylglycinamide ribonucleotide amidotransferase; Formylglycinamide ribotide amidotransferase

Phosphoribosylformylglycinamidine Synthase (PFAS)
CCC G245
HGNC 8863
MGI 2684864
PubMed 16544324
RGD 1304926
UniProt O15067
Wiki PFAS
Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis.
PFAS catalyzes the fourth step of IMP biosynthesis.The human GARS-AIRS-GART locus, located on chromosome 21, encodes 3 of the 10 enzymatic steps necessary for the conversion of phosphoribosyl pyrophosphate to inosine monophosphate by the de novo purine pathway. The 3 enzyme activities are encoded in a linear, nonoverlapping fashion on the GARS-AIRS-GART mRNA, starting at the 5-prime end of the cDNA. These enzymatic activities catalyze the second, fifth, and third step of the de novo purine pathway, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG245Hu01 Recombinant Phosphoribosylformylglycinamidine Synthase (PFAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG245Mu01 Recombinant Phosphoribosylformylglycinamidine Synthase (PFAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoribosylformylglycinamidine Synthase (PFAS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoribosylformylglycinamidine Synthase (PFAS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoribosylformylglycinamidine Synthase (PFAS) ELISA Kit Customized Service Offer
  1. "Human phosphoribosylformylglycinamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis."Gene 239:381-391(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]