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Proteoglycan 4 (PRG4)

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MSF; CACP; HAPO; JCAP; SZP; Megakaryocyte Stimulating factor; Articular Superficial Zone Protein; Camptodactyly; Arthropathy,Coxa Vara,Pericarditis Syndrome

Proteoglycan 4 (PRG4)
CCC G246
HGNC 9364
MGI 1891344
PubMed 17343281
UniProt Q92954
Wiki PRG4
Proteoglycan 4 is an approximately 345-kD proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. The cDNA encodes a protein of 1,404 amino acids with a somatomedin B homology domain, heparin-binding domains, multiple mucin-like repeats, a hemopexin domain, and an aggregation domain. There are 3 consensus sequences for N-glycosylation and 1 chondroitin sulfate substitution site. The locus for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31. This protein may act as a joint/intimal cell lubricant, and cell overgrowth may be primary to the pathogenesis of this protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG246Hu01 Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG246Hu01 Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
MAG246Hu21 Monoclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
Assay Kits SEG246Hu ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG246Mu01 Recombinant Proteoglycan 4 (PRG4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG246Mu01 Polyclonal Antibody to Proteoglycan 4 (PRG4) WB; IHC; ICC; IP.
Assay Kits SEG246Mu ELISA Kit for Proteoglycan 4 (PRG4) Enzyme-linked immunosorbent assay for Antigen Detection.
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