≡

p53 Responsive Gene 3 (PRG3)

[Edit]

AIFM2; AMID; Apoptosis-Inducing Factor,Mitochondrion-Associated 2; p53-responsive gene 3; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death

p53 Responsive Gene 3 (PRG3)
CCC G247
HGNC 21411
MGI 1918611
PubMed 12135761
RGD 1304964
UniProt Q9BRQ8
Inactivation of the p53 tumor suppressor protein (TP53) has been observed in a large number of human cancers. Overexpression of p53 induces either growth arrest or apoptosis. The growth arrest function of p53 is mediated by induction of p21 (CDKN1A). To identify genes that may be involved in p53-dependent apoptosis, Horikoshi et al. (1999) used differential display analysis to compare mRNA from a human colon cancer cell line undergoing a very early stage of p53-induced apoptosis to mRNA from the same cell line before undergoing apoptosis. They identified 6 p53-responsive genes, PRG1 to PRG6. PRG3 was upregulated in the apoptotic cells. Northern blot analysis of the p53-induced colon cancer cell line detected a 4-kb PRG3 transcript.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG247Hu01 Recombinant p53 Responsive Gene 3 (PRG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG247Hu01 Polyclonal Antibody to p53 Responsive Gene 3 (PRG3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for p53 Responsive Gene 3 (PRG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p53 Responsive Gene 3 (PRG3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG247Mu01 Recombinant p53 Responsive Gene 3 (PRG3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to p53 Responsive Gene 3 (PRG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p53 Responsive Gene 3 (PRG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p53 Responsive Gene 3 (PRG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p53 Responsive Gene 3 (PRG3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant p53 Responsive Gene 3 (PRG3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to p53 Responsive Gene 3 (PRG3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to p53 Responsive Gene 3 (PRG3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for p53 Responsive Gene 3 (PRG3) CLIA Kit Customized Service Offer
n/a ELISA Kit for p53 Responsive Gene 3 (PRG3) ELISA Kit Customized Service Offer
  1. "A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)."FEBS Lett. 524:163-171(2002) [PubMed] [Europe PMC] [Abstract]
  2. "AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis."J. Biol. Chem. 277:25617-25623(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Lung.
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "AMID is a p53-inducible gene downregulated in tumors."Oncogene 23:6815-6819(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity."J. Biol. Chem. 280:30735-30740(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]