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Guanylate Cyclase Activator 1A, Retina (GUCA1A)

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GCAP; COD3; GCAP1; GUCA; GUCA1; C6orf131; Cone Dystrophy 3; Guanylyl cyclase-activating protein 1

Guanylate Cyclase Activator 1A, Retina (GUCA1A)
CCC G255
HGNC 4678
MGI 102770
PubMed 24024198
RGD 1308712
UniProt P43080
Wiki GUCA1A
GUCA1A plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching.
The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase Activator 1A, Retina (GUCA1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase Activator 1A, Retina (GUCA1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Cyclase Activator 1A, Retina (GUCA1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Cyclase Activator 1A, Retina (GUCA1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Cyclase Activator 1A, Retina (GUCA1A) ELISA Kit Customized Service Offer
  1. "Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene."J. Biol. Chem. 269:31080-31089(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1."Hum. Mol. Genet. 7:273-277(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease."Biochim. Biophys. Acta 1498:233-251(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Autosomal dominant cone and cone-rod dystrophy with mutations in the guanylate cyclase activator 1A gene-encoding guanylate cyclase activating protein-1."Arch. Ophthalmol. 119:96-105(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy."Am. J. Hum. Genet. 69:471-480(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration."Invest. Ophthalmol. Vis. Sci. 45:3863-3870(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)."Invest. Ophthalmol. Vis. Sci. 46:1124-1132(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A)."Mol. Vis. 11:143-151(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase."Hum. Mutat. 30:E782-E796(2009) [PubMed] [Europe PMC] [Abstract]