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Chromobox Homolog 8 (CBX8)

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PC3; HPC3; RC1; Polycomb 3; Rectachrome 1

Chromobox Homolog 8 (CBX8)
CCC G268
HGNC 15962
MGI 1353589
PubMed 22094252
RGD 1565375
UniProt Q9HC52
Wiki CBX8
Chromobox protein homolog 8 is a protein encoded by the CBX8 gene.Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Chromobox Homolog are highly conserved adapter molecules, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromere, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at single nucleosome level and gene repression by heterochromatization of euchromatin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 8 (CBX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 8 (CBX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 8 (CBX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 8 (CBX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 8 (CBX8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 8 (CBX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 8 (CBX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 8 (CBX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 8 (CBX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 8 (CBX8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 8 (CBX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 8 (CBX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 8 (CBX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 8 (CBX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 8 (CBX8) ELISA Kit Customized Service Offer
  1. "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties."J. Biol. Chem. 275:28785-28792(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."Oncogene 20:411-419(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."Mol. Cell. Biol. 22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."PLoS ONE 4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Recognition and specificity determinants of the human cbx chromodomains."J. Biol. Chem. 286:521-529(2011) [PubMed] [Europe PMC] [Abstract]