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Chromobox Homolog 1 (CBX1)

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CBX1; CBX; HP1-BETA; HP1Hs-beta; M31; MOD1; Heterochromatin protein p25; Heterochromatin protein 1 homolog beta; Modifier 1 protein

Chromobox Homolog 1 (CBX1)
CCC G269
HGNC 1551
MGI 105369
PubMed 9169582
RGD 1310714
UniProt P83916
Wiki CBX1
CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The family of Heterochromatin Protein 1 (HP1) ("Chromobox Homolog", CBX) are highly conserved adapter molecules, which have important functions in the cell nucleus. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 1 (CBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 1 (CBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 1 (CBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 1 (CBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 1 (CBX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 1 (CBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 1 (CBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 1 (CBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 1 (CBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 1 (CBX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromobox Homolog 1 (CBX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromobox Homolog 1 (CBX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromobox Homolog 1 (CBX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromobox Homolog 1 (CBX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromobox Homolog 1 (CBX1) ELISA Kit Customized Service Offer
  1. "Heterochromatin protein HP1Hsbeta (p25beta) and its localization with centromeres in mitosis."Chromosoma 106:11-19(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. , Submitted (DEC-2008) to UniProtKB
  4. "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells."Chromosoma 108:220-234(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31."EMBO J. 18:1923-1938(1999) [PubMed] [Europe PMC] [Abstract]
  6. "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer." Cell 115:523-535(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69."EMBO Rep. 6:675-680(2005) [PubMed] [Europe PMC] [Abstract]
  8. "In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation."Mol. Cell. Biol. 25:4552-4564(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
  11. "ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1."J. Biol. Chem. 285:18-29(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10."PLoS ONE 5:E10620-E10620(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding."Structure 14:703-712(2006) [PubMed] [Europe PMC] [Abstract]