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Prohibitin 2 (PHB2)

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BAP; p22; BCAP37; Bap37; PNAS-141; REA; Repressor Of Estrogen Receptor Activity; D-prohibitin; B-cell receptor-associated protein BAP37

Prohibitin 2 (PHB2)
CCC G296
HGNC 30306
MGI 102520
PubMed 22384121
RGD 620203
UniProt Q99623
Wiki PHB2
The deduced 299-amino acid protein contains 4 potential phosphorylation sites, a nuclear receptor interaction box, and a nuclear localization motif. REA suppressed activation of a reporter gene in a dose-dependent manner. REA had no effect on reporter activity in the absence of liganded ER, and it had no effect on the transcriptional activities of other hormone receptors. Mutation analysis showed that an N-terminal domain and a central domain of REA were required for its repressor activity. REA interacted directly with ER-alpha in an in vitro pull-down assay. REA did not interfere with the ability of ER-alpha to bind to estrogen response element DNA, but it competed with the coactivator SRC1 (NCOA1) for modulation of ER-alpha transcriptional activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG296Hu01 Recombinant Prohibitin 2 (PHB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Prohibitin 2 (PHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prohibitin 2 (PHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prohibitin 2 (PHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prohibitin 2 (PHB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prohibitin 2 (PHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prohibitin 2 (PHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prohibitin 2 (PHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prohibitin 2 (PHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prohibitin 2 (PHB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prohibitin 2 (PHB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prohibitin 2 (PHB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prohibitin 2 (PHB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prohibitin 2 (PHB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prohibitin 2 (PHB2) ELISA Kit Customized Service Offer
  1. "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] [Abstract]
  2. "An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens."Proc. Natl. Acad. Sci. U.S.A. 96:6947-6952(1999) [PubMed] [Europe PMC] [Abstract].
  3. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Skin.
  7. , Submitted (MAR-2009) to UniProtKB
  8. "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence."Exp. Cell Res. 265:262-273(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "ZNF703 gene amplification at 8p12 specifies luminal B breast cancer." EMBO Mol. Med. 3:153-166(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function."Mol. Cell. Biol. 31:3845-3856(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]