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Far Upstream Element Binding Protein 1 (FUBP1)

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FBP; FUBP; hDH V; DNA helicase V

Far Upstream Element Binding Protein 1 (FUBP1)
CCC G310
HGNC 4004
MGI 1196294
PubMed 22588899
UniProt Q96AE4
Wiki FUBP1
FUBP1 encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.Expression of FBP in human leukemia cells stimulated the activity of a MYC promoter in a FUSE-dependent manner. Northern blot analysis revealed that expression of the 2.6-kb FBP mRNA declined upon differentiation, suggesting that FUSE-binding activity may be regulated transcriptionally. In addition, by sequence analysis of FBP cDNAs, the authors found evidence that FBP activity may also be regulated by alternative splicing, translation efficiency, and posttranslational modification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG310Hu01 Recombinant Far Upstream Element Binding Protein 1 (FUBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Far Upstream Element Binding Protein 1 (FUBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Far Upstream Element Binding Protein 1 (FUBP1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG310Hu ELISA Kit for Far Upstream Element Binding Protein 1 (FUBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Far Upstream Element Binding Protein 1 (FUBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Far Upstream Element Binding Protein 1 (FUBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Far Upstream Element Binding Protein 1 (FUBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Far Upstream Element Binding Protein 1 (FUBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Far Upstream Element Binding Protein 1 (FUBP1) ELISA Kit Customized Service Offer
  1. "A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif."Genes Dev. 8:465-480(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of human DNA helicase V with the far upstream element-binding protein."Nucleic Acids Res. 29:1061-1067(2001) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (DEC-2008) to UniProtKB
  6. "Large-scale proteomic analysis of the human spliceosome."Genome Res. 12:1231-1245(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The FBP interacting repressor targets TFIIH to inhibit activated transcription."Mol. Cell 5:331-341(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation."Nat. Genet. 34:330-336(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Structure and dynamics of KH domains from FBP bound to single-stranded DNA."Nature 415:1051-1056(2002) [PubMed] [Europe PMC] [Abstract]