Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61)
[Edit]CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10
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CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.
The transcription of immediate-early genes is induced rapidly when cells are stimulated by growth factors or transforming oncogenes.The human CYR61 gene encodes a predicted 382-amino acid protein that is 93% identical to the mouse protein, and contains 10% cysteine residues and a 24-amino acid N-terminal signal sequence. Northern blot analysis revealed 2.5-kb and minor 4-kb CYR61 mRNAs that are expressed widely at varying levels.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG313Mu01 | Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG313Mu02 | Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG313Mu01 | Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | WB; IHC; ICC; IP. |
| PAG313Mu02 | Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG313Mu | ELISA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) | ELISA Kit Customized Service Offer |
- "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p."Oncogene 14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract]
- "Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system."Mol. Pathol. 50:310-316(1997) [PubMed] [Europe PMC] [Abstract]
- "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]
- "Organization and expression of the Cyr61 gene in normal human fibroblasts."J. Biomed. Sci. 9:59-67(2002) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts."J. Biol. Chem. 276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract]
- "Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3."J. Biol. Chem. 273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract]
- "Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)."J. Biol. Chem. 274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract]
- "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]
- "CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain."J. Biol. Chem. 276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract]