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Tryptophan Hydroxylase 2 (TPH2)

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NTPH; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2

Tryptophan Hydroxylase 2 (TPH2)
CCC G343
HGNC 20692
MGI 2651811
PubMed 22693556
RGD 631332
UniProt Q8IWU9
Wiki TPH2
TPH2 encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by the mouse ortholog.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG343Hu01 Recombinant Tryptophan Hydroxylase 2 (TPH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG343Hu01 Polyclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
MAG343Hu21 Monoclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
Assay Kits SEG343Hu ELISA Kit for Tryptophan Hydroxylase 2 (TPH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG343Mu01 Recombinant Tryptophan Hydroxylase 2 (TPH2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG343Mu02 Recombinant Tryptophan Hydroxylase 2 (TPH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG343Mu01 Polyclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
PAG343Mu02 Polyclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
Assay Kits SEG343Mu ELISA Kit for Tryptophan Hydroxylase 2 (TPH2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG343Ra01 Recombinant Tryptophan Hydroxylase 2 (TPH2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG343Ra21 Monoclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
PAG343Ra01 Polyclonal Antibody to Tryptophan Hydroxylase 2 (TPH2) WB; IHC; ICC; IP.
Assay Kits SEG343Ra ELISA Kit for Tryptophan Hydroxylase 2 (TPH2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Synthesis of serotonin by a second tryptophan hydroxylase isoform."Science 299:76-76(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder." Hum. Mol. Genet. 17:87-97(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Alternative splicing and extensive RNA editing of human TPH2 transcripts."PLoS ONE 5:E8956-E8956(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression."Neuron 45:11-16(2005) [PubMed] [Europe PMC] [Abstract]
  7. "A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder."Mol. Psychiatry 13:365-367(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Functional properties of missense variants of human tryptophan hydroxylase 2."Hum. Mutat. 30:787-794(2009) [PubMed] [Europe PMC] [Abstract]