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Guanine Monophosphate Synthetase (GMPS)

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GMP Synthase; Glutamine amidotransferase; GMP synthase [glutamine-hydrolyzing]

Guanine Monophosphate Synthetase (GMPS)
CCC G354
HGNC 4378
MGI 2448526
PubMed 23816837
RGD 1310063
UniProt P49915
Wiki GMPS
In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase (EC 6.3.5.2), which catalyzes the amination of XMP to GMP. Both IMP dehydrogenase and GMP synthetase exhibit elevated levels of activity in rapidly proliferating cells such as neoplastic and regenerating tissues.
The open reading frame encoded a protein of 693 amino acids with a predicted molecular mass of 76,725. The cDNA complemented a guaA mutant of Escherichia coli. A single 2.4-kb mRNA was demonstrated. DNA hybridization analysis suggested that human GMP synthetase is encoded by 1 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG354Hu01 Recombinant Guanine Monophosphate Synthetase (GMPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Monophosphate Synthetase (GMPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Monophosphate Synthetase (GMPS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Monophosphate Synthetase (GMPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Monophosphate Synthetase (GMPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Monophosphate Synthetase (GMPS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Monophosphate Synthetase (GMPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Monophosphate Synthetase (GMPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Monophosphate Synthetase (GMPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Monophosphate Synthetase (GMPS) ELISA Kit Customized Service Offer
  1. "Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA."J. Biol. Chem. 269:23830-23837(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5-prime monophosphate synthetase) gene."Blood 96:4360-4362(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Substrate specificity and oligomerization of human GMP synthetase."J. Mol. Biol. 425:4323-4333(2013) [PubMed] [Europe PMC] [Abstract]