≡

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)

[Edit]

ATP2B; DAR; SERCA2; Calcium pump 2; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)
CCC G374
HGNC 812
MGI 88110
PubMed 11244492
RGD 2174
UniProt P16615
Wiki ATP2A2
ATP2A2 is one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed, in smooth muscle and nonmuscle tissues such as in adult skin epidermis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG374Hu01 Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG374Hu02 Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG374Hu01 Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) WB; IHC; ICC; IP.
MAG374Hu21 Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) WB; IHC; ICC; IP.
PAG374Hu02 Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) WB; IHC; ICC; IP.
Assay Kits SEG374Hu ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG374Mu01 Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Positive Control; Immunogen; SDS-PAGE; WB.
RPG374Mu02 Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG374Mu01 Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) WB; IHC; ICC; IP.
PAG374Mu02 Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) WB; IHC; ICC; IP.
Assay Kits SEG374Mu ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Polyclonal Antibody Customized Service Offer
Assay Kits SEG374Ra ELISA Kit for ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene."J. Biol. Chem. 263:15024-15031(1988) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a new SERCA2 splice variant regulated during monocytic differentiation."Biochem. Biophys. Res. Commun. 303:676-684(2003) [PubMed] [Europe PMC] [Abstract]
  6. "TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis."Mol. Cell. Biol. 24:1758-1768(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging."Am. J. Physiol. 290:H2220-H2227(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival."Mol. Biol. Cell 20:306-318(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters."Proc. Natl. Acad. Sci. U.S.A. 108:19234-19239(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Spectrum of novel ATP2A2 mutations in patients with Darier's disease."Hum. Mol. Genet. 8:1611-1619(1999) [PubMed] [Europe PMC] [Abstract]
  17. "ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class."Hum. Mol. Genet. 8:1621-1630(1999) [PubMed] [Europe PMC] [Abstract]
  18. "ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes."Hum. Mol. Genet. 8:1631-1636(1999) [PubMed] [Europe PMC] [Abstract]
  19. "Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease."Nat. Genet. 21:271-277(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Acrokeratosis verruciformis of Hopf is caused by mutation in ATP2A2: evidence that it is allelic to Darier's disease."J. Invest. Dermatol. 120:229-232(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c)."Biochem. J. 395:249-258(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Three-base deletion mutation c.120_122delGTT in ATP2A2 leads to the unique phenotype of comedonal Darier disease."Br. J. Dermatol. 162:687-689(2010) [PubMed] [Europe PMC] [Abstract]