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ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a)

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ATP1AL1; Potassium-Transporting ATPase Alpha Chain 2; Proton Pump; Non-Gastric H(+)/K(+)ATPase Alpha Subunit; Sodium/Potassium ATPase,Alpha Polypeptide-Like

ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a)
CCC G398
HGNC 13816
MGI 1926943
PubMed 22179016
RGD 620569
UniProt P54707
Wiki ATP12A
ATP12a belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.
The deduced 1,039-amino acid protein has a calculated molecular mass of 114.5 kD. ATP1AL1 has all the features of catalytic subunits of P-type ion-transporting ATPases, including a catalytic phosphorylation site (asp391), components of the ATP-binding site (asp732 and asp736), and 10 potential transmembrane domains spaced throughout the molecule. Highest ATP1AL1 expression was detected in skin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG398Hu01 Recombinant ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase, H+/K+ Transporting, Nongastric Alpha Polypeptide (ATP12a) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of the entire cDNA encoded by ATP1AL1 --a member of the human Na,K/H,K-ATPase gene family."FEBS Lett. 349:144-150(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase."Genomics 32:317-327(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase."FEBS Lett. 278:91-94(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Multiple genes encode the human Na+,K+-ATPase catalytic subunit."Proc. Natl. Acad. Sci. U.S.A. 84:4039-4043(1987) [PubMed] [Europe PMC] [Abstract]
  8. "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit."FEBS Lett. 217:275-278(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit."FEBS Lett. 440:320-324(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue."Cell. Physiol. Biochem. 28:1287-1294(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]