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ATPase Class I Type 8A1 (ATP8A1)

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ATPIA; Phospholipid-transporting ATPase IA; Chromaffin granule ATPase II; P4-ATPase flippase complex alpha subunit ATP8A1

ATPase Class I Type 8A1 (ATP8A1)
CCC G400
HGNC 13531
MGI 1330848
PubMed 23269685
UniProt Q9Y2Q0
The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI).
ATP8A1 is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene.The deduced 1,164 amino acid protein contains characteristics of members of the third subfamily of P-type ATPases.Transcripts encoding proteins with the insert were detected in brain, skeletal muscle, and heart, and transcripts encoding proteins without the sequence were detected in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8A1 (ATP8A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8A1 (ATP8A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8A1 (ATP8A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8A1 (ATP8A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8A1 (ATP8A1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATPase Class I Type 8A1 (ATP8A1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATPase Class I Type 8A1 (ATP8A1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATPase Class I Type 8A1 (ATP8A1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATPase Class I Type 8A1 (ATP8A1) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATPase Class I Type 8A1 (ATP8A1) ELISA Kit Customized Service Offer
  1. "Cloning, expression, and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase."Biochem. Biophys. Res. Commun. 257:333-339(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
  7. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]
  8. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]