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Desmocollin 2 (DSC2)

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ARVD11; CDHF2; DG2; DGII/III; Cadherin family member 2; Desmosomal glycoprotein III

Desmocollin 2 (DSC2)
CCC G436
HGNC 3036
MGI 103221
PubMed 20621329
RGD 1309426
UniProt Q02487
Wiki DSC2
Desmocollin-2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.Exon 16 is alternatively spliced, giving rise to the a and b forms of the protein. A remarkable degree of conservation of intron position with other cadherins was observed.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG436Hu01 Recombinant Desmocollin 2 (DSC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG436Hu01 Polyclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
MAG436Hu21 Monoclonal Antibody to Desmocollin 2 (DSC2) WB; IHC; ICC; IP.
Assay Kits SEG436Hu ELISA Kit for Desmocollin 2 (DSC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmocollin 2 (DSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmocollin 2 (DSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmocollin 2 (DSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmocollin 2 (DSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmocollin 2 (DSC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Desmocollin 2 (DSC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Desmocollin 2 (DSC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Desmocollin 2 (DSC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Desmocollin 2 (DSC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Desmocollin 2 (DSC2) ELISA Kit Customized Service Offer
  1. "Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing."J. Biol. Chem. 266:10438-10445(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2."Am. J. Hum. Genet. 79:978-984(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy."Mol. Genet. Metab. 95:74-80(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]