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Statherin (STATH)

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Statherin (STATH)
CCC G441
HGNC 11369
PubMed 15041485
UniProt P02808
Wiki STATH
Statherin may play an important role in the maintenance of oral health since, like the proline-rich proteins, it binds calcium and inhibits crystal growth. Statherin also inhibits spontaneous precipitation of calcium phosphate salts. Thus, statherin and PRPs may prevent build-up of harmful deposits in the salivary glands and on the tooth surfaces.
Statherin is a highly stable salivary protein of low molecular mass (5,380). Sabatini et al. synthesized mixed oligonucleotides based on the known amino acid sequence of statherin and used these to screen a cDNA library constructed from human parotid gland mRNA. A study of DNA from human-hamster somatic cell hybrids indicated that statherin is coded by a single-copy gene located in region 4q11-q13. Dentinogenesis imperfectaand perhaps juvenile periodontitis are coded in the same region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG441Hu01 Recombinant Statherin (STATH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG441Hu01 Polyclonal Antibody to Statherin (STATH) WB; IHC; ICC; IP.
LAG441Hu71 Biotin-Linked Polyclonal Antibody to Statherin (STATH) WB; IHC; ICC.
MAG441Hu21 Monoclonal Antibody to Statherin (STATH) WB; IHC; ICC; IP.
MAG441Hu22 Monoclonal Antibody to Statherin (STATH) WB; IHC; ICC; IP.
Assay Kits SEG441Hu ELISA Kit for Statherin (STATH) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva."Am. J. Hum. Genet. 41:1048-1060(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence."Biochem. Biophys. Res. Commun. 149:784-790(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and sequence determination of the gene encoding human salivary statherin."Gene 89:245-251(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva."J. Biol. Chem. 252:1689-1695(1977) [PubMed] [Europe PMC] [Abstract]
  8. "Multiple forms of statherin in human salivary secretions."Arch. Oral Biol. 36:529-534(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides."J. Dent. Res. 66:462-466(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Tyrosine sulfation of statherin."Int. J. Biol. Sci. 3:237-241(2007) [PubMed] [Europe PMC] [Abstract]
  11. "HPLC-MS characterization of cyclo-statherin Q-37, a specific cyclization product of human salivary statherin generated by transglutaminase 2."J. Sep. Sci. 29:2600-2608(2006) [PubMed] [Europe PMC] [Abstract]