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Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1)

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HISPPD2A; IPS1; VIP1; Histidine Acid Phosphatase Domain Containing 2A; InsP6/PP-IP5 kinase 1; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1)
CCC G447
HGNC 29023
MGI 2443281
PubMed 23682967
RGD 1311552
UniProt Q6PFW1
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD2A has both IP6 kinase and PP-IP5 (also called IP7) kinase activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively.
IP6K phosphorylates IP6 to produce IP7 with the pyrophosphate at position 5 of the inositol ring. The yeast homolog, Vip1, produced different IP7 products, with pyrophosphates at positions 4 or 6. Both yeast and human proteins could generate IP8 containing 2 pyrophosphates. Mutation analysis showed that the ATP-grasp domain of yeast Vip1 was sufficient for IP6 kinase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG447Hu01 Recombinant Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG447Mu01 Recombinant Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphosphoinositol Pentakisphosphate Kinase 1 (PPIP5K1) ELISA Kit Customized Service Offer
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  13. "Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain."Biochem. J. 434:415-426(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]