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Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2)

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HISPPD1; VIP2; Histidine Acid Phosphatase Domain Containing 1; InsP6 and PP-IP5 kinase 2; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2)
CCC G448
HGNC 29035
MGI 2142810
PubMed 23240582
UniProt O43314
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively.
The deduced 1,243-amino acid protein had an apparent molecular mass of more than 100 kD by SDS-PAGE.The deduced 1,222-amino acid PPIP5K2 protein has a calculated molecular mass of 138 kD. It shares 66% amino acid identity with rat and human PPIP5K1, with most divergence occurring in the C termini. VIP2 also showed kinase activity in human embryonic kidney cells engineered to produce high levels of IP6 and 5-PP-IP5.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG448Hu01 Recombinant Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Diphosphoinositol Pentakisphosphate Kinase 2 (PPIP5K2) ELISA Kit Customized Service Offer
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  10. "Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain."Biochem. J. 434:415-426(2011) [PubMed] [Europe PMC] [Abstract]
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