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N-Acetylneuraminic Acid Phosphatase (NANP)

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C20orf147; HDHD4; Haloacid Dehalogenase-Like Hydrolase Domain Containing 4; Neu5Ac-9-Pase

N-Acetylneuraminic Acid Phosphatase (NANP)
CCC G449
HGNC 16140
MGI 1914561
PubMed 17286574
RGD 1306009
UniProt Q8TBE9
Neu5Ac-9-phosphate phosphatase (Neu5Ac-9-Pase; EC 3.1.3.29) dephosphorylates Neu5Ac-9-phosphate to form N-acetylneuraminate (Neu5Ac), the main form of sialic acid in vertebrates that has important roles in protein-protein and cell-cell recognition.
Purified recombinant human HDHD4 catalyzed the dephosphorylation of Neu5Ac-9-phosphate with a catalytic efficiency more than 2 orders of magnitude higher than for any other substrate tested. The 248-amino acid human HDHD4 protein has 3 motifs found in phosphatases of the haloacid dehalogenase (HAD) family: the first with 2 extremely conserved aspartates, the second comprising a conserved serine or threonine, and the third comprising a conserved lysine and 2 conserved aspartates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetylneuraminic Acid Phosphatase (NANP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG449Mu01 Recombinant N-Acetylneuraminic Acid Phosphatase (NANP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant N-Acetylneuraminic Acid Phosphatase (NANP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to N-Acetylneuraminic Acid Phosphatase (NANP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) CLIA Kit Customized Service Offer
n/a ELISA Kit for N-Acetylneuraminic Acid Phosphatase (NANP) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase."Glycobiology 16:165-172(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The crystal structure of human N-acetylneuraminic acid phosphatase, NANP."Submitted (DEC-2008) to the PDB data bank