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Adenylosuccinate Lyase (ADSL)

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AMPS; ASase; Adenylosuccinase

Adenylosuccinate Lyase (ADSL)
CCC G452
HGNC 291
MGI 103202
PubMed 16839792
RGD 1307617
UniProt P30566
Wiki ADSL
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP.
Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. Ubiquitously expressed. Both isoforms are produced by all tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG452Hu01 Recombinant Adenylosuccinate Lyase (ADSL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Adenylosuccinate Lyase (ADSL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylosuccinate Lyase (ADSL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylosuccinate Lyase (ADSL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylosuccinate Lyase (ADSL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenylosuccinate Lyase (ADSL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenylosuccinate Lyase (ADSL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylosuccinate Lyase (ADSL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylosuccinate Lyase (ADSL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylosuccinate Lyase (ADSL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adenylosuccinate Lyase (ADSL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adenylosuccinate Lyase (ADSL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adenylosuccinate Lyase (ADSL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adenylosuccinate Lyase (ADSL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adenylosuccinate Lyase (ADSL) ELISA Kit Customized Service Offer
  1. "Mapping of the human adenylosuccinate lyase (ADSL) gene to chromosome 22q13.1-->q13.2."Cytogenet. Cell Genet. 64:201-203(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients."Hum. Mol. Genet. 9:1501-1513(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A mutation in adenylosuccinate lyase associated with mental retardation and autistic features."Nat. Genet. 1:59-63(1992) [PubMed] [Europe PMC] [Abstract]