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Nardilysin (NRD1)

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NRD-C; N-Arginine Dibasic Convertase

Nardilysin (NRD1)
CCC G453
HGNC 7995
MGI 1201386
PubMed 22653443
RGD 3210
UniProt O43847
Wiki Nardilysin
Endoproteases that activate protein precursors by cleavage at basic residues belong to the 4 classes of proteases: aspartyl, serine, thiol, and metalloenzymes. NRD1, a metalloendopeptidase that cleaves peptide substrates at the N terminus of arginine residues in dibasic moieties, had been previously purified from rat testis. By screening a rat testis cDNA library with oligonucleotides based on the sequence of the purified Nrd1 protein, The predicted 1,161-amino acid Nrd1 protein has a calculated molecular mass of 133 kD, consistent with the mass of the largest form of the purified enzyme. Nrd1 contains a putative signal peptide, a 71-residue acidic stretch, and a zinc-binding motif. The amino acid sequence of rat Nrd1 is 31% identical to that of human insulinase (IDE).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG453Hu01 Recombinant Nardilysin (NRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Nardilysin (NRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nardilysin (NRD1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG453Hu ELISA Kit for Nardilysin (NRD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG453Mu01 Recombinant Nardilysin (NRD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Nardilysin (NRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nardilysin (NRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nardilysin (NRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nardilysin (NRD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nardilysin (NRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nardilysin (NRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nardilysin (NRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nardilysin (NRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nardilysin (NRD1) ELISA Kit Customized Service Offer
  1. "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues."Genomics 47:238-245(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family."Biochem. J. 327:773-779(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
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  5. "Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines."Biochem. J. 351:755-764(2000) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]