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5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR)

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MSR; cblE; Methionine Synthase Reductase,Mitochondrial

5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR)
CCC G461
HGNC 7473
MGI 1891037
PubMed 11807890
RGD 1308671
UniProt Q9UBK8
Wiki MTRR
Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor.
MTRR encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG461Mu01 Recombinant 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG461Ra01 Recombinant 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) CLIA Kit Customized Service Offer
n/a ELISA Kit for 5-Methyltetrahydrofolate Homocysteine Methyltransferase Reductase (MTRR) ELISA Kit Customized Service Offer
  1. "Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene."Gene 240:75-88(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria."Proc. Natl. Acad. Sci. U.S.A. 95:3059-3064(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Restricted role for methionine synthase reductase defined by subcellular localization."Mol. Genet. Metab. 94:68-77(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry."Biochemistry 46:11833-11844(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism."Hum. Mol. Genet. 8:2009-2016(1999) [PubMed] [Europe PMC] [Abstract]
  11. "A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida."Mol. Genet. Metab. 67:317-323(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida."Am. J. Hum. Genet. 71:1222-1226(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association."Mol. Genet. Metab. 85:220-227(2005) [PubMed] [Europe PMC] [Abstract]