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Dopa Decarboxylase (DDC)

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AADC; Aromatic L-Amino Acid Decarboxylase; DOPA decarboxylase

Dopa Decarboxylase (DDC)
CCC G474
HGNC 2719
MGI 94876
PubMed 16740595
RGD 2494
UniProt P20711
Wiki DDC
DOPA decarboxylase (EC 4.1.1.28) is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters, dopamine and serotonin. Following the hydroxylation of tyrosine to form L-dihydroxyphenylalanine (L-DOPA), catalyzed by tyrosine hydroxylase (TH), DDC decarboxylates L-DOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5-OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate-dependent enzyme.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG474Hu01 Recombinant Dopa Decarboxylase (DDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG474Hu01 Polyclonal Antibody to Dopa Decarboxylase (DDC) WB; IHC; ICC; IP.
MAG474Hu21 Monoclonal Antibody to Dopa Decarboxylase (DDC) WB; IHC; ICC; IP.
Assay Kits SEG474Hu ELISA Kit for Dopa Decarboxylase (DDC) Enzyme-linked immunosorbent assay for Antigen Detection.
HEG474Hu High Sensitive ELISA Kit for Dopa Decarboxylase (DDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG474Mu01 Recombinant Dopa Decarboxylase (DDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Dopa Decarboxylase (DDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopa Decarboxylase (DDC) Polyclonal Antibody Customized Service Offer
Assay Kits SEG474Mu ELISA Kit for Dopa Decarboxylase (DDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dopa Decarboxylase (DDC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dopa Decarboxylase (DDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dopa Decarboxylase (DDC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dopa Decarboxylase (DDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dopa Decarboxylase (DDC) ELISA Kit Customized Service Offer
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  2. "Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs."Genomics 13:469-471(1992) [PubMed] [Europe PMC] [Abstract]
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  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases."Proc. Natl. Acad. Sci. U.S.A. 108:20514-20519(2011) [PubMed] [Europe PMC] [Abstract]
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  12. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  13. ErratumNat. Genet. 23:373-373(1999)
  14. "Levodopa-responsive aromatic L-amino acid decarboxylase deficiency."Ann. Neurol. 55:435-438(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis."Neurology 62:1058-1065(2004) [PubMed] [Europe PMC] [Abstract]