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Spermidine Synthase (SRM)

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SPS1; SRML1; SPDSY; Putrescine aminopropyltransferase

Spermidine Synthase (SRM)
CCC G486
HGNC 11296
MGI 102690
RGD 620796
UniProt P19623
Wiki SRM
The biosynthesis of polyamines, which are universally essential for cellular functions, takes place from arginine and methionine and involves 4 distinct enzymes: spermidine synthase (EC 2.5.1.16), ornithine decarboxylase , S-adenosyl-L-methionine decarboxylase, and spermine synthase. An open reading frame for a 302-amino acid polypeptide was found. As determined from the intensity of the hybridization signal observed in analysis of DNA from somatic cell hybrids, it seemed likely that the functional gene is located at the former site. it comprises 5,818 nucleotides from the cap site to the last A of the putative polyadenylation signal with 8 exons and 7 intervening sequences. PCR analysis of DNA obtained from human/hamster somatic cell hybrids showed segregation with human chromosome 1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG486Hu01 Recombinant Spermidine Synthase (SRM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Spermidine Synthase (SRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermidine Synthase (SRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermidine Synthase (SRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermidine Synthase (SRM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermidine Synthase (SRM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermidine Synthase (SRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermidine Synthase (SRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermidine Synthase (SRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermidine Synthase (SRM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spermidine Synthase (SRM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spermidine Synthase (SRM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spermidine Synthase (SRM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spermidine Synthase (SRM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spermidine Synthase (SRM) ELISA Kit Customized Service Offer
  1. "Human spermidine synthase: cloning and primary structure."DNA Cell Biol. 9:103-110(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Human spermidine synthase gene: structure and chromosomal localization."DNA Cell Biol. 10:467-474(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Structure and mechanism of spermidine synthases."Biochemistry 46:8331-8339(2007) [PubMed] [Europe PMC] [Abstract]