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Farnesyltransferase Alpha (FNTa)

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FPTA; PTAR2; PGGT1A; Protein Prenyltransferase Alpha Subunit Repeat Containing 2; CAAX farnesyltransferase subunit alpha; Ras proteins prenyltransferase subunit alpha

Farnesyltransferase Alpha (FNTa)
CCC G487
HGNC 3782
MGI 104683
PubMed 8276393
RGD 2625
UniProt P49354
Wiki FNTA
CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits.
FNTa encodes the alpha subunit of these transferases. The best characterized of the prenyltransferases, CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the remarkable property of farnesylating peptides as short as 4 residues in length that conform to the CAAX consensus sequence.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG487Hu01 Recombinant Farnesyltransferase Alpha (FNTa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAG487Hu21 Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; IHC; ICC; IP.
PAG487Hu01 Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEG487Hu ELISA Kit for Farnesyltransferase Alpha (FNTa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesyltransferase Alpha (FNTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesyltransferase Alpha (FNTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyltransferase Alpha (FNTa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesyltransferase Alpha (FNTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesyltransferase Alpha (FNTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesyltransferase Alpha (FNTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesyltransferase Alpha (FNTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyltransferase Alpha (FNTa) ELISA Kit Customized Service Offer
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  2. "Mutational analysis of alpha-subunit of protein farnesyltransferase. Evidence for a catalytic role."J. Biol. Chem. 268:1383-1390(1993) [PubMed] [Europe PMC] [Abstract]
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  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics."Proc. Natl. Acad. Sci. U.S.A. 98:12948-12953(2001) [PubMed] [Europe PMC] [Abstract]
  15. "3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency." J. Med. Chem. 45:2388-2409(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents."J. Med. Chem. 46:2973-2984(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity."Biochemistry 43:6877-6884(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity."J. Mol. Biol. 343:417-433(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Conversion of protein farnesyltransferase to a geranylgeranyltransferase."Biochemistry 45:9746-9755(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase."Chem. Biol. 16:181-192(2009) [PubMed] [Europe PMC] [Abstract]