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RAB Geranylgeranyltransferase Beta Subunit (RABGGTb)

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GGTB; Geranylgeranyl transferase type II subunit beta; Type II protein geranyl-geranyltransferase subunit beta; Geranylgeranyl transferase type-2 subunit beta

RAB Geranylgeranyltransferase Beta Subunit (RABGGTb)
CCC G489
HGNC 9796
MGI 99537
PubMed 18419622
RGD 3530
UniProt P53611
Wiki RABGGTb
Rabggtb is ubiquitously expressed in adult mice, but displays a varying pattern of expression during embryonic development. Its expression was detected in whole embryos during early embryonic stages, but was specifically concentrated in the developing brain, heart, and liver during gestation stages E11.5 and E13.5.
The cDNA showed 82.4% identity over 341 bp of coding sequence to a rat sequence encoding the catalytic subunit of RAB geranylgeranyl transferase. The amino acid sequences of the 2 genes are 91.1% similar.it encodes a 331-amino acid polypeptide, which is very well conserved among both mammalian and lower eukaryotic species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Beta Subunit (RABGGTb) ELISA Kit Customized Service Offer
  1. "Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II."Eur. J. Biochem. 239:362-368(1996) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter."Genomics 38:133-140(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II."J. Biol. Chem. 276:32875-32882(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A."Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate."Biochem. J. 415:67-75(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]