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RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa)

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PTAR3; Protein Prenyltransferase Alpha Subunit Repeat Containing 3; Geranylgeranyl transferase type-2 subunit alpha; Rab geranylgeranyltransferase subunit alpha

RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa)
CCC G490
HGNC 9795
MGI 1860443
PubMed 11136552
RGD 621697
UniProt Q92696
RABGGTa encodes a 567-amino acid polypeptide. Homology to the transglutaminase gene, TGM1, which maps to 14q11, indicated that this subunit was located on the same chromosomal band; Southern blot analysis confirmed this locus. Further analysis revealed that the RABGGTA and TGM1 genes are located only 2 kb apart in head-to-tail tandem arrangement; however, these 2 genes are not likely to be functionally related.
The third identified prenyltransferase is a GGTase that recognizes proteins that terminate in the sequence cys-X-cys or cys-cys. Its substrates include a large family of related membrane-associated GTP-binding proteins termed RAB proteins. RAB GGTase is composed of 2 tightly associated subunits, alpha (RABGGTA) and beta (RABGGTB).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Geranylgeranyltransferase Alpha Subunit (RABGGTa) ELISA Kit Customized Service Offer
  1. "cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter."Genomics 38:133-140(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The genes encoding geranylgeranyl transferase alpha-subunit and transglutaminase 1 are very closely linked but not functionally related in terminally differentiating keratinocytes."Biochem. Biophys. Res. Commun. 235:10-14(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A."Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate."Biochem. J. 415:67-75(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]