Secretoglobin Family 2A, Member 1 (SCGB2A1)

The uteroglobin gene family includes the uteroglobin (UGB) and mammaglobin (MGB) genes. The authors isolated a full-length MGB2 cDNA by RACE PCR using mRNA from a human breast cancer cell line.

The MGB2 gene contains 3 exons. The predicted 95-amino acid MGB2 protein contains the conserved residues characteristic of the uteroglobin family. MGB2 shares 58% amino acid sequence identity with MGB and 23% identity with UGB. MGB2 expression in normal human breast, uterus, and salivary gland, but not in prostate or stomach. Northern blot analysis detected MGB2 expression in normal breast and breast tumor samples, with an apparent overexpression in tumor samples compared with patient-matched normal samples. MGB2 expression in 2 of 8 normal samples and 2 of 8 tumor samples.