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Lipin 1 (LPIN1)

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Phosphatidate phosphatase LPIN1

Lipin 1 (LPIN1)
CCC G501
HGNC 13345
MGI 1891340
PubMed 11138012
RGD 1307646
UniProt Q14693
Wiki LPIN1
Lipin-1 has phosphatidate phosphatase activity.This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.
Database analysis identified the human LPIN1 gene, as well as the human and mouse LPIN2 and LPIN3 genes. Consistent with the observed reduction of adipose tissue mass in fld mice, wildtype Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of 3T3-L1 preadipocytes. The results indicated that lipin is required for normal adipose tissue development, and provided a candidate gene for human lipodystrophy.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lipin 1 (LPIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lipin 1 (LPIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lipin 1 (LPIN1) Polyclonal Antibody Customized Service Offer
Assay Kits SEG501Hu ELISA Kit for Lipin 1 (LPIN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG501Mu01 Recombinant Lipin 1 (LPIN1) Positive Control; Immunogen; SDS-PAGE; WB.
RPG501Mu02 Recombinant Lipin 1 (LPIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG501Mu01 Polyclonal Antibody to Lipin 1 (LPIN1) WB; IHC; ICC; IP.
PAG501Mu02 Polyclonal Antibody to Lipin 1 (LPIN1) WB; IHC; ICC; IP.
Assay Kits SEG501Mu ELISA Kit for Lipin 1 (LPIN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG501Ra01 Recombinant Lipin 1 (LPIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG501Ra01 Polyclonal Antibody to Lipin 1 (LPIN1) WB; IHC; ICC; IP.
MAG501Ra21 Monoclonal Antibody to Lipin 1 (LPIN1) WB; IHC; ICC; IP.
Assay Kits SEG501Ra ELISA Kit for Lipin 1 (LPIN1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms."J. Biol. Chem. 285:14628-14638(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of single-nucleotide polymorphisms in the human LPIN1 gene."J. Hum. Genet. 47:370-372(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood."Am. J. Hum. Genet. 83:489-494(2008) [PubMed] [Europe PMC] [Abstract]
  12. ErratumAm. J. Hum. Genet. 84:95-95(2008)
  13. "Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway."J. Biol. Chem. 287:3123-3137(2012) [PubMed] [Europe PMC] [Abstract]