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Baculoviral IAP Repeat Containing Protein 7 (BIRC7)

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KIAP; LIVIN; ML-IAP; MLIAP; RNF50; Melanoma Inhibitor Of Apoptosis Protein; Kidney Inhibitor Of Apoptosis Protein; Livin Inhibitor-Of-Apoptosis; RING finger protein 50

Baculoviral IAP Repeat Containing Protein 7 (BIRC7)
CCC G518
HGNC 13702
MGI 2676458
PubMed 22902369
RGD 1562883
UniProt Q96CA5
Wiki BIRC7
Baculoviral IAP repeat-containing protein 7 is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Polyclonal Antibody Customized Service Offer
Assay Kits SEG518Hu ELISA Kit for Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 7 (BIRC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 7 (BIRC7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Baculoviral IAP Repeat Containing Protein 7 (BIRC7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Baculoviral IAP Repeat Containing Protein 7 (BIRC7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Baculoviral IAP Repeat Containing Protein 7 (BIRC7) ELISA Kit Customized Service Offer
  1. "KIAP, a novel member of the inhibitor of apoptosis protein family."Biochem. Biophys. Res. Commun. 279:820-831(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern."FEBS Lett. 495:56-60(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Livin, a novel inhibitor of apoptosis protein family member."J. Biol. Chem. 276:3238-3246(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas."Curr. Biol. 10:1359-1366(2000) [PubMed] [Europe PMC] [Abstract]
  8. "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)."J. Biol. Chem. 277:12275-12279(2002) [PubMed] [Europe PMC] [Abstract]
  9. "IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition."Mol. Cell. Biol. 22:1754-1766(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway."Cell Death Differ. 13:2079-2088(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin."Apoptosis 12:1129-1142(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Manipulation of NK cytotoxicity by the IAP family member Livin."Eur. J. Immunol. 37:3467-3476(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Challenge and promise: roles for Livin in progression and therapy of cancer."Mol. Cancer Ther. 7:3661-3669(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Research progress on Livin protein: an inhibitor of apoptosis."Mol. Cell. Biochem. 357:39-45(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)."Biochemistry 42:8223-8231(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP."Biochem. J. 385:11-20(2005) [PubMed] [Europe PMC] [Abstract]