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Ras Related Nuclear Protein (Ran)

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ARA24; Gsp1; TC4; GTP-binding nuclear protein Ran; Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4

Ras Related Nuclear Protein (Ran)
CCC G521
HGNC 9846
MGI 1333112
PubMed 7519373
RGD 620367
UniProt P62826
Wiki RAN
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related Nuclear Protein (Ran) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related Nuclear Protein (Ran) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related Nuclear Protein (Ran) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related Nuclear Protein (Ran) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related Nuclear Protein (Ran) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related Nuclear Protein (Ran) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related Nuclear Protein (Ran) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related Nuclear Protein (Ran) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related Nuclear Protein (Ran) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related Nuclear Protein (Ran) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Related Nuclear Protein (Ran) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Related Nuclear Protein (Ran) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Related Nuclear Protein (Ran) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Related Nuclear Protein (Ran) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Related Nuclear Protein (Ran) ELISA Kit Customized Service Offer
  1. "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line."Mol. Cell. Biol. 10:1793-1798(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase."Cell 66:347-360(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis."J. Cell Biol. 120:313-323(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator."J. Biol. Chem. 274:20229-20234(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. , Submitted (FEB-2006) to UniProtKB
  9. , Submitted (MAR-2007) to UniProtKB
  10. "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide."Proc. Natl. Acad. Sci. U.S.A. 88:10830-10834(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta."Proc. Natl. Acad. Sci. U.S.A. 93:7059-7062(1996) [PubMed] [Europe PMC] [Abstract]
  12. "CRM1 is an export receptor for leucine-rich nuclear export signals."Cell 90:1051-1060(1997) [PubMed] [Europe PMC] [Abstract]
  13. "The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP."J. Biol. Chem. 273:33414-33422(1998) [PubMed] [Europe PMC] [Abstract]
  14. "CRM1-mediated recycling of snurportin 1 to the cytoplasm."J. Cell Biol. 145:255-264(1999) [PubMed] [Europe PMC] [Abstract]
  15. "RanBP3 influences interactions between CRM1 and its nuclear protein export substrates."EMBO Rep. 2:926-932(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export."J. Cell Biol. 153:1391-1402(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M."J. Biol. Chem. 278:49573-49581(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707."Mol. Cell. Biol. 23:4598-4610(2003) [PubMed] [Europe PMC] [Abstract]
  19. "A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein."Mol. Cell. Biol. 23:8751-8761(2003) [PubMed] [Europe PMC] [Abstract]
  20. "A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling."Biochem. Biophys. Res. Commun. 313:320-326(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex."Mol. Cell 16:761-775(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  23. "A survivin-ran complex regulates spindle formation in tumor cells."Mol. Cell. Biol. 28:5299-5311(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities."Mol. Cell. Proteomics 7:2199-2214(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  26. "The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle."PLoS ONE 4:E7020-E7020(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  30. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form."Nature 374:378-381(1995) [PubMed] [Europe PMC] [Abstract]
  33. "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp."Nature 399:230-237(1999) [PubMed] [Europe PMC] [Abstract]
  34. "Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport."Nature 398:39-46(1999) [PubMed] [Europe PMC] [Abstract]