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TYRO Protein Tyrosine Kinase Binding Protein (TYROBP)

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DAP12; KARAP; PLOSL; Killer Activating Receptor Associated Protein; DNAX-Activation Protein 12

TYRO Protein Tyrosine Kinase Binding Protein (TYROBP)
CCC G524
HGNC 12449
MGI 1277211
PubMed 10888890
RGD 1303081
UniProt O43914
Wiki TYROBP
TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG524Hu01 Recombinant TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG524Hu01 Polyclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) WB; IHC; ICC; IP.
MAG524Hu21 Monoclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) WB; IHC; ICC; IP.
Assay Kits SEG524Hu ELISA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for TYRO Protein Tyrosine Kinase Binding Protein (TYROBP) ELISA Kit Customized Service Offer
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  7. "Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts."Nat. Genet. 25:357-361(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."J. Immunol. 164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms."Neurology 59:1105-1107(2002) [PubMed] [Europe PMC] [Abstract]
  10. "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development."Mol. Immunol. 38:817-824(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular characterization of a novel immune receptor restricted to the monocytic lineage."J. Immunol. 173:6703-6711(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates."FASEB J. 20:1964-1973(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular and functional characterization of CD300b, a new activating immunoglobulin receptor able to transduce signals through two different pathways."J. Immunol. 177:2819-2830(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells."Blood 111:688-698(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The structural basis for intramembrane assembly of an activating immunoreceptor complex."Nat. Immunol. 11:1023-1029(2010) [PubMed] [Europe PMC] [Abstract]