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Iodotyrosine Deiodinase (IYD)

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DEHAL1; TDH4; C6orf71; Iodotyrosine dehalogenase 1

Iodotyrosine Deiodinase (IYD)
CCC G528
HGNC 21071
MGI 1917587
PubMed 15289438
RGD 1309288
UniProt Q6PHW0
Wiki IYD
Iodotyrosine deiodinase facilitates iodide salvage in thyroid by catalyzing deiodination of mono- and diiodotyrosine, the halogenated byproducts of thyroid hormone production.Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
Iodotyrosine Deiodinasecatalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iodotyrosine Deiodinase (IYD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iodotyrosine Deiodinase (IYD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iodotyrosine Deiodinase (IYD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iodotyrosine Deiodinase (IYD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iodotyrosine Deiodinase (IYD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iodotyrosine Deiodinase (IYD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iodotyrosine Deiodinase (IYD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iodotyrosine Deiodinase (IYD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iodotyrosine Deiodinase (IYD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iodotyrosine Deiodinase (IYD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Iodotyrosine Deiodinase (IYD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Iodotyrosine Deiodinase (IYD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Iodotyrosine Deiodinase (IYD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Iodotyrosine Deiodinase (IYD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Iodotyrosine Deiodinase (IYD) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel thyroidal gene encoding proteins with a conserved nitroreductase domain."J. Endocrinol. Invest. 25 Suppl. 7:S23-S23(2002)
  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site."FASEB J. 18:1574-1576(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the iodotyrosine deiodinase gene and hypothyroidism."N. Engl. J. Med. 358:1811-1818(2008) [PubMed] [Europe PMC] [Abstract]