Lysophosphatidylcholine Acyltransferase 3 (LPCAT3)
[Edit]MBOAT5; C3F; OACT5; Nessy; LPSAT; Membrane Bound O-AcylTransferase Domain Containing 5; Lysophospholipid Acyltransferase 5; Lysophosphatidylserine acyltransferase
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The deduced 487-amino acid human and mouse MBOAT5 proteins contain 11 predicted transmembrane domains and share 88% amino acid identity. Human MBOAT5 shares 35% amino acid identity with Drosophila nessy.The deduced protein contains 10 putative transmembrane domains and a C-terminal endoplasmic reticulum (ER) retention motif (KKxx). RT-PCR detected ubiquitous Lpcat3 expression, with highest level in testis. Lpcat3 colocalized with an ER marker protein in transfected Chinese hamster ovary cells.
Knockdown of Lpcat3 in mouse melanoma cells with small interfering RNA significantly reduced cellular acyltransferase activity toward endogenous lysophosphatidylcholine, lysophosphatidylethanolamine, and lysophosphatidylserine.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG531Hu01 | Recombinant Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAG531Hu01 | Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC |
| LAG531Hu71 | Biotin-Linked Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC; ICC. | |
| LAG531Hu81 | FITC-Linked Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC; ICC; IF. | |
| MAG531Hu21 | Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB | |
| LAG531Hu54 | APC-Linked Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC; ICC, IP. | |
| Assay Kits | SEG531Hu | ELISA Kit for Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG531Mu01 | Recombinant Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG531Mu02 | Recombinant Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAG531Mu01 | Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC; ICC; IP. |
| PAG531Mu02 | Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | WB; IHC; ICC; IP. | |
| Assay Kits | SEG531Mu | ELISA Kit for Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Lysophosphatidylcholine Acyltransferase 3 (LPCAT3) | ELISA Kit Customized Service Offer |
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Pancreas.
- "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination."Genome Res. 7:268-280(1997) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterization of a major liver lysophosphatidylcholine acyltransferase."J. Biol. Chem. 283:8258-8265(2008) [PubMed] [Europe PMC] [Abstract]
- "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils."J. Biol. Chem. 283:30235-30245(2008) [PubMed] [Europe PMC] [Abstract]