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Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ)

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G-ALPHA-q; GAQ

Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ)
CCC G548
HGNC 4390
MGI 95776
PubMed 23904987
RGD 620770
UniProt P50148
Wiki GNAQ
GNAQ is 359 amino acids long and is identical in all but 1 amino acid residue to the mouse protein. Analysis of human genomic DNA revealed an intronless sequence with strong homology to human GNAQ cDNA. In comparison to GNAQ cDNA, this genomic DNA sequence included several small deletions and insertions that altered the reading frame, multiple single based changes, and a premature termination codon in the open reading frame, all hallmarks of a processed pseudogene. Probes derived from human GNAQ cDNA sequence mapped both chromosomes 2 and 9 in higher constringency genomic blot analyses of DNA from a panel of human/rodent hybrid cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanine Nucleotide Binding Protein Q Polypeptide (GNAQ) ELISA Kit Customized Service Offer
  1. "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene."Genomics 30:470-475(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Human G(alpha q): cDNA and tissue distribution."Biochim. Biophys. Acta 1281:125-128(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences."Biochem. J. 318:1023-1031(1996) [PubMed] [Europe PMC] [Abstract]
  4. "G alpha q cDNA sequence from human platelets."Thromb. Res. 91:29-32(1998) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain."Biol. Psychiatry 32:549-579(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways."Biochem. J. 312:151-158(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)."J. Biol. Chem. 277:40751-40759(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."Biochemistry 47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Expression of G protein alphaq subunit is decreased in lymphocytes from rheumatoid arthritis patients and is correlated with disease activity."Scand. J. Immunol. 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ."N. Engl. J. Med. 368:1971-1979(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi."Nature 457:599-602(2009) [PubMed] [Europe PMC] [Abstract]
  16. "GNAQ and GNA11 mutations in melanocytomas of the central nervous system."Acta Neuropathol. 123:457-459(2012) [PubMed] [Europe PMC] [Abstract]