Solute Carrier Family 34, Member 2 (SLC34A2)
[Edit]NAPI-3B; NaPi3b; Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B
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The deduced 690-amino acid SLC34A2 protein is a type 2 phosphate transporter. It contains 8 predicted transmembrane domains and a cysteine-rich N-terminal region. SLC34A2 shares 78% amino acid identity with the mouse sodium-dependent phosphate transporter IIb.
Functional studies showed that SLC34A2 is a sodium-dependent phosphate transporter that is strongly sensitive to pH, with phosphate uptake increased at more acidic pH. Northern blot analysis detected a 4.2-kb SLC34A2 transcript in several human tissues of epithelial origin; kidney also contained high levels of a 2.4-kb transcript. SLC34A2 was most abundantly expressed in lung, with moderate expression in kidney, pancreas, and prostate.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPG571Hu01 | Recombinant Solute Carrier Family 34, Member 2 (SLC34A2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPG571Hu02 | Recombinant Solute Carrier Family 34, Member 2 (SLC34A2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPG571Hu03 | Recombinant Solute Carrier Family 34, Member 2 (SLC34A2) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | n/a | Monoclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Solute Carrier Family 34, Member 2 (SLC34A2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Solute Carrier Family 34, Member 2 (SLC34A2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Solute Carrier Family 34, Member 2 (SLC34A2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Solute Carrier Family 34, Member 2 (SLC34A2) | ELISA Kit Customized Service Offer |
- "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine."Biochem. Biophys. Res. Commun. 258:578-582(1999) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)."Genomics 62:281-284(1999) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor."Am. J. Physiol. 280:C628-C636(2001) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)."Genes Chromosomes Cancer 37:58-71(2003) [PubMed] [Europe PMC] [Abstract]
- "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis."Am. J. Hum. Genet. 79:650-656(2006) [PubMed] [Europe PMC] [Abstract]