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Solute Carrier Family 30, Member 5 (SLC30A5)

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ZTL1; ZnT-5; ZNT5; ZNTL1; Zinc Transporter 5; ZnT-like transporter 1

Solute Carrier Family 30, Member 5 (SLC30A5)
CCC G576
HGNC 19089
MGI 1916298
PubMed 19451265
RGD 1306931
UniProt Q8TAD4
The deduced 523-amino acid protein contains 12 predicted membrane-spanning domains with extracellular N and C termini. Between transmembrane domains 9 and 10, ZTL1 has a zinc-binding histidine-rich intracellular loop. ZTL1 shares 34% identity with ZNT1 (SLC30A1) over a 122-amino acid stretch, and it shares significant homology with several rodent zinc transporters. Northern blot analysis detected 2.0- and 5.0-kb transcripts in CaCo2 cell line RNA. RT-PCR of mouse tissues detected ubiquitous expression, with highest level in kidney and lowest level in liver.The deduced 765-amino acid protein has 15 predicted membrane-spanning domains and a calculated molecular mass of about 84 kD. Western blot analysis of the full-length protein expressed in HeLa cells indicated an apparent molecular mass of about 55 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 30, Member 5 (SLC30A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 30, Member 5 (SLC30A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 30, Member 5 (SLC30A5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG576Mu01 Recombinant Solute Carrier Family 30, Member 5 (SLC30A5) Positive Control; Immunogen; SDS-PAGE; WB.
RPG576Mu02 Recombinant Solute Carrier Family 30, Member 5 (SLC30A5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG576Mu01 Polyclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) WB; IHC; ICC; IP.
PAG576Mu02 Polyclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) WB; IHC; ICC; IP.
Assay Kits SEG576Mu ELISA Kit for Solute Carrier Family 30, Member 5 (SLC30A5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 30, Member 5 (SLC30A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 30, Member 5 (SLC30A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 30, Member 5 (SLC30A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 30, Member 5 (SLC30A5) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells."J. Biol. Chem. 277:19049-19055(2002) [PubMed] [Europe PMC] [Abstract]
  2. "A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane."J. Biol. Chem. 277:22789-22797(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study."Biochem. Pharmacol. 68:699-709(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells."J. Biol. Chem. 280:30956-30962(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane."J. Biol. Chem. 280:637-643(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]