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Pyrophosphatase 1 (PPA1)

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Ppase; IOPPP; PP1; Cytosolic Inorganic Pyrophosphatase; Pyrophosphate phospho-hydrolase

Pyrophosphatase 1 (PPA1)
CCC G603
HGNC 9226
MGI 97831
PubMed 23626709
RGD 1589773
UniProt Q15181
Inorganic pyrophosphates are generated as byproducts of many biosynthetic reactions, including DNA and RNA synthesis, fatty acid and amino acid activation, and cyclic nucleotide synthesis. Inorganic pyrophosphatases (EC 3.6.1.1), such as PPA1, maintain the thermodynamic favorability of these reactions by catalyzing the hydrolysis of pyrophosphates into organic phosphates, which are then exported across the cell membrane.
The deduced 289-amino acid protein has a calculated molecular mass of 32.7 kD and shares 94% amino acid identity with bovine pyrophosphatase. Northern blot analysis detected a 1.4-kb PPA1 transcript in all tissues examined. RNA dot blot analysis confirmed ubiquitous PPA1 expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrophosphatase 1 (PPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrophosphatase 1 (PPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrophosphatase 1 (PPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrophosphatase 1 (PPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrophosphatase 1 (PPA1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrophosphatase 1 (PPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrophosphatase 1 (PPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrophosphatase 1 (PPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrophosphatase 1 (PPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrophosphatase 1 (PPA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyrophosphatase 1 (PPA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyrophosphatase 1 (PPA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyrophosphatase 1 (PPA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyrophosphatase 1 (PPA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyrophosphatase 1 (PPA1) ELISA Kit Customized Service Offer
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  5. , Submitted (DEC-2008) to UniProtKB
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  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]