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Tubulin Polymerization Promoting Protein 3 (TPPP3)

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CGI-38; p25gamma; p20

Tubulin Polymerization Promoting Protein 3 (TPPP3)
CCC G625
HGNC 24162
MGI 1915221
RGD 1305061
UniProt Q9BW30
Microtubules (MTs) play an important role in cell division, and their functions are regulated by a set of microtubule-associated proteins (MAPs).
Tubulin polymerization promoting protein family member 3 (TPPP3), also known as p20, is a new member of the tubulin polymerization promoting protein (TPPP) family. TPPP3 specifically binds to MTs and positively regulates MTs assembly, which leads to significant ultrastructural alterations of the MTs network.
However, the physiological function of TPPP3 is still largely unknown. TPPP3 played a crucial role in cell mitosis by regulating centrosomes amplification and/or spindles translocation processes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Polymerization Promoting Protein 3 (TPPP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Polymerization Promoting Protein 3 (TPPP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tubulin Polymerization Promoting Protein 3 (TPPP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tubulin Polymerization Promoting Protein 3 (TPPP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tubulin Polymerization Promoting Protein 3 (TPPP3) ELISA Kit Customized Service Offer
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions."Biochemistry 45:13818-13826(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation."Mol. Cell. Biochem. 333:91-98(2010) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Solution NMR structure of tubulin polymerization-promoting protein family member 3 from Homo sapiens."Submitted (FEB-2009) to the PDB data bank