Triggering Receptor Expressed On Myeloid Cells 5 (TREM5)

CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells. The deduced 201-amino acid type I integral membrane protein has a predicted molecular mass of 22.7 kD and contains a 17-amino acid signal peptide, a single V-like Ig extracellular domain, a 29-amino acid membrane proximal region with a high proportion of proline, serine, and threonine residues, and many potential O-glycosylation sites.

CD300B has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail, giving it the ability to signal through 2 independent pathways. CD300LB was detected in all human myelomonocytic cell lines tested, with weak expression in NK and B cell lines.