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Proline Glutamate And Leucine Rich Protein 1 (PELP1)

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MNAR; HMX3; Modulator of non-genomic activity of estrogen receptor; Transcription factor HMX3

Proline Glutamate And Leucine Rich Protein 1 (PELP1)
CCC G634
HGNC 30134
MGI 1922523
PubMed 23975430
RGD 1306320
UniProt Q8IZL8
Wiki PELP1
PELP1 is a coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors.The deduced 1,282-amino acid protein contains an N-terminal domain with 9 LxxLL motifs, followed by 2 central cysteine-rich regions, which are separated by a nuclear localization signal, and 2 C-terminal proline-rich regions, which are separated by an acidic region. The 2 cysteine-rich regions may form 3 zinc fingers. PELP1 also contains several consensus phosphorylation sites. RNA dot blot analysis detected PELP1 expression in most tissues tested, with highest expression in testis, mammary gland, brain, skeletal muscle, and lung. PELP1 localized predominantly in the nuclear fraction of fractionated cells, but some PELP1 also associated with the cytosolic fraction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline Glutamate And Leucine Rich Protein 1 (PELP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline Glutamate And Leucine Rich Protein 1 (PELP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proline Glutamate And Leucine Rich Protein 1 (PELP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proline Glutamate And Leucine Rich Protein 1 (PELP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proline Glutamate And Leucine Rich Protein 1 (PELP1) ELISA Kit Customized Service Offer
  1. "Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade."Proc. Natl. Acad. Sci. U.S.A. 99:14783-14788(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha."J. Biol. Chem. 276:38272-38279(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Functional interactions between the estrogen receptor coactivator PELP1/MNAR and retinoblastoma protein."J. Biol. Chem. 278:22119-22127(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc."Mol. Endocrinol. 18:1096-1108(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Potential role of a novel transcriptional coactivator PELP1 in histone H1 displacement in cancer cells."Cancer Res. 64:6416-6423(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The transcriptional corepressor, PELP1, recruits HDAC2 and masks histones using two separate domains."J. Biol. Chem. 279:50930-50941(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors."J. Clin. Endocrinol. Metab. 89:6130-6138(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Functional implications of altered subcellular localization of PELP1 in breast cancer cells."Cancer Res. 65:7724-7732(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation."Cancer Res. 65:5571-5577(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway."J. Biol. Chem. 281:15394-15404(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK."J. Biol. Chem. 281:4395-4403(2006) [PubMed] [Europe PMC] [Abstract]
  15. "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression."Proc. Natl. Acad. Sci. U.S.A. 103:5308-5313(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)."Mol. Endocrinol. 21:1847-1860(2007) [PubMed] [Europe PMC] [Abstract]
  17. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  18. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."Mol. Cell. Proteomics 11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  25. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]