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Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1)

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P130; NOPP130; NOPP140; NS5ATP13; Nucleolar Phosphoprotein p130; 140 kDa nucleolar phosphoprotein; Hepatitis C virus NS5A-transactivated protein 13

Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1)
CCC G644
HGNC 15608
MGI 1918019
PubMed 19541936
RGD 621578
UniProt Q14978
NOLC1contains a motif that consists of a long serine-rich stretch interspersed with acidic residues; this motif is repeated 10 times. The amino acid sequence of p130 is 74% identical to that of rat nucleolar protein Nopp140, with the N and C termini and the serine-acidic stretches showing the most conservation.A cellular casein kinase II activity is responsible for the highly phosphorylated state of p130. During mitosis, p130 may be subject to additional phosphorylation by cdc2 kinase. p130 is localized to the nucleoli of interphase cells but is undetectable in cells in the mitotic phase. P130 appears as dot-like granules that are assembled in the nucleoplasm at telophase and early G1-phase before migrating into the nucleoli to form part of the dense fibrillar component, the subnucleolar region for pre-rRNA synthesis and processing.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG644Hu01 Recombinant Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG644Hu01 Polyclonal Antibody to Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar And Coiled Body Phosphoprotein 1 (NOLC1) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  5. "Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130."Biochem. Biophys. Res. Commun. 221:581-587(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+."Biochem. Biophys. Res. Commun. 230:370-375(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization."Mol. Cell. Biol. 19:8536-8546(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]