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Chloride Channel Protein 6 (CLCN6)

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CLC-6; Chloride Transport Protein 6

Chloride Channel Protein 6 (CLCN6)
CCC G666
HGNC 2024
MGI 1347049
PubMed 11080594
RGD 1305379
UniProt P51797
Wiki CLCN6
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.
The predicted 869-amino acid protein was called CLC6 by them. The amino acid sequence of CLCN6 is 45% identical to that of CLCN7 but only 23 to 29% identical to the sequences of other known CLCNs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Protein 6 (CLCN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Protein 6 (CLCN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Protein 6 (CLCN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Protein 6 (CLCN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Protein 6 (CLCN6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Protein 6 (CLCN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Protein 6 (CLCN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Protein 6 (CLCN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Protein 6 (CLCN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Protein 6 (CLCN6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Protein 6 (CLCN6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Protein 6 (CLCN6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Protein 6 (CLCN6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Protein 6 (CLCN6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Protein 6 (CLCN6) ELISA Kit Customized Service Offer
  1. "ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family."FEBS Lett. 377:15-20(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of ClC-6 (a member of the ClC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific."Biochem. J. 325:269-276(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes."Biochim. Biophys. Acta 1447:100-106(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of CLCN voltage-gated chloride channel genes in human blood vessels."J. Mol. Cell. Cardiol. 31:657-666(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains."PLoS ONE 2:E474-E474(2007) [PubMed] [Europe PMC] [Abstract]