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Chloride Channel Accessory 2 (CLCA2)

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CaCC3; CLCRG2; Chloride Channel,Calcium Activated,Family Member 2; Calcium-activated chloride channel protein 3

Chloride Channel Accessory 2 (CLCA2)
CCC G668
HGNC 2016
MGI 2139758
PubMed 22990203
RGD 1304894
UniProt Q9UQC9
Wiki CLCA2
Chloride Channel Accessory 2 belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions.
Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Accessory 2 (CLCA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Accessory 2 (CLCA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Accessory 2 (CLCA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Accessory 2 (CLCA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Accessory 2 (CLCA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Accessory 2 (CLCA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Accessory 2 (CLCA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Accessory 2 (CLCA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Accessory 2 (CLCA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Accessory 2 (CLCA2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland."Am. J. Physiol. 276:C1261-C1270(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea."FEBS Lett. 455:295-301(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of a Ca(2+)-activated chloride channel from human corneal epithelium."Curr. Eye Res. 21:918-925(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2."Cancer Res. 59:5488-5491(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer."DNA Cell Biol. 20:331-338(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis."J. Biol. Chem. 276:25438-25446(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Calcium-activated chloride channel-2 in human epithelia."J. Histochem. Cytochem. 52:415-418(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia."Acta Histochem. 106:421-425(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium."Cell Tissue Res. 323:177-182(2006) [PubMed] [Europe PMC] [Abstract]
  12. "The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment."J. Biol. Chem. 281:29448-29454(2006) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]