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Chloride Channel Accessory 1 (CLCA1)

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CaCC1; CLCRG1; Chloride Channel,Calcium Activated,Family Member 1; Calcium-activated chloride channel protein 1

Chloride Channel Accessory 1 (CLCA1)
CCC G669
HGNC 2015
MGI 1346342
PubMed 23112050
RGD 621100
UniProt A8K7I4
Wiki CLCA1
CLCA1 encodes a member of the calcium sensitive chloride conductance protein family. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined.
The CLCA1 cDNA encodes a deduced 914-amino acid protein with a calculated molecular mass of 100.9 kD. Human CLCLA1 shares 67% amino acid identity with mouse Clca1, bovine CLCA1, and bovine Lu-ECAM-1. The predicted human CLCLA1 protein has a signal sequence, 4 transmembrane domains, a large hydrophobic region at its C terminus, and a number of potential glycosylation and phosphorylation sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG669Hu01 Recombinant Chloride Channel Accessory 1 (CLCA1) Positive Control; Immunogen; SDS-PAGE; WB.
APG669Hu01 Active Chloride Channel Accessory 1 (CLCA1) Cell culture; Activity Assays.
Antibodies PAG669Hu01 Polyclonal Antibody to Chloride Channel Accessory 1 (CLCA1) WB; IHC; ICC; IP.
MAG669Hu21 Monoclonal Antibody to Chloride Channel Accessory 1 (CLCA1) WB; IHC; ICC; IP.
Assay Kits SEG669Hu ELISA Kit for Chloride Channel Accessory 1 (CLCA1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Accessory 1 (CLCA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Accessory 1 (CLCA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Accessory 1 (CLCA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Accessory 1 (CLCA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Accessory 1 (CLCA1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chloride Channel Accessory 1 (CLCA1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chloride Channel Accessory 1 (CLCA1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chloride Channel Accessory 1 (CLCA1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chloride Channel Accessory 1 (CLCA1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chloride Channel Accessory 1 (CLCA1) ELISA Kit Customized Service Offer
  1. "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins."Genomics 54:200-214(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea."FEBS Lett. 455:295-301(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation."J. Biol. Chem. 287:42138-42149(2012) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer."DNA Cell Biol. 20:331-338(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway."Am. J. Respir. Crit. Care Med. 165:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma."J. Allergy Clin. Immunol. 109:246-250(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps."Acta Oto-Laryngol. 125:745-752(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa."J. Allergy Clin. Immunol. 115:266-271(2005) [PubMed] [Europe PMC] [Abstract]
  11. "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels."J. Biol. Chem. 280:27205-27212(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium."Am. J. Respir. Cell Mol. Biol. 33:523-530(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Histamine induces MUC5AC expression via a hCLCA1 pathway."Pharmacology 80:219-226(2007) [PubMed] [Europe PMC] [Abstract]