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Lens Epithelium Derived Growth Factor (LEDGF)

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PSIP1; p75; p52; DFS70; PAIP; PSIP2; PC4 And SFRS1 Interacting Protein 1; CLL-associated antigen KW-7; Dense fine speckles 70 kDa protein; Transcriptional coactivator p75/p52

Lens Epithelium Derived Growth Factor (LEDGF)
CCC G671
HGNC 9527
MGI 2142116
PubMed 22773103
RGD 631439
UniProt O75475
Wiki PSIP1
PSIP1 is a misnomer as the protein is present in most tissues and has no direct role in the development of Lens epithelium. LEDGF/p75, a transcription coactivator, gained prominence as the host factor which assists HIV integration and is probably the only protein whose knock down severely affects the HIV integration levels. The interaction between HIV integrase and human LEDGF/p75 is a promising target for anti-HIV drug discovery. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG671Hu01 Recombinant Lens Epithelium Derived Growth Factor (LEDGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Lens Epithelium Derived Growth Factor (LEDGF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lens Epithelium Derived Growth Factor (LEDGF) Polyclonal Antibody Customized Service Offer
Assay Kits SEG671Hu ELISA Kit for Lens Epithelium Derived Growth Factor (LEDGF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG671Mu01 Recombinant Lens Epithelium Derived Growth Factor (LEDGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG671Mu01 Polyclonal Antibody to Lens Epithelium Derived Growth Factor (LEDGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lens Epithelium Derived Growth Factor (LEDGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lens Epithelium Derived Growth Factor (LEDGF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPG671Ra01 Recombinant Lens Epithelium Derived Growth Factor (LEDGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAG671Ra01 Polyclonal Antibody to Lens Epithelium Derived Growth Factor (LEDGF) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Lens Epithelium Derived Growth Factor (LEDGF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lens Epithelium Derived Growth Factor (LEDGF) ELISA Kit Customized Service Offer
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  2. "Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts."Biochem. Biophys. Res. Commun. 267:373-381(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing."Gene 242:265-273(2000) [PubMed] [Europe PMC] [Abstract]
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  8. "Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain."Exp. Eye Res. 79:941-948(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase."J. Biol. Chem. 279:55570-55577(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The interaction of LEDGF/p75 with integrase is lentiviral-specific and promotes DNA binding."J. Biol. Chem. 280:17841-17847(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering."J. Cell Sci. 118:1733-1743(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2."Mol. Cell 2:751-759(1998) [PubMed] [Europe PMC] [Abstract]
  13. "t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia."Leuk. Res. 29:467-470(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ."J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75."Nat. Struct. Mol. Biol. 12:526-532(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75."Proc. Natl. Acad. Sci. U.S.A. 102:17308-17313(2005) [PubMed] [Europe PMC] [Abstract]