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Coproporphyrinogen Oxidase (CPOX)

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HCP; CPO; CPX; Coproporphyrinogenase; Coproporphyria; Harderoporphyria; Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

Coproporphyrinogen Oxidase (CPOX)
CCC G673
HGNC 2321
MGI 104841
PubMed 21824890
RGD 1311817
UniProt P36551
Wiki CPOX
Coproporphyrinogen III oxidase is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. The gene spans about 14 kb and consists of 7 exons and 6 introns. Introns vary in size from 269 bp to 5 kb and all have consensus sequences at their boundaries. This fragment was used as a hybridization probe to isolate full-length CPO clones from a mouse erythroleukemia cell cDNA library. Sequence analysis demonstrated that CPO comprises 354 amino acid residues with a putative leader sequence of 31 amino acid residues, the mature protein having 323 amino acid residues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coproporphyrinogen Oxidase (CPOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Polyclonal Antibody Customized Service Offer
Assay Kits SEG673Hu ELISA Kit for Coproporphyrinogen Oxidase (CPOX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coproporphyrinogen Oxidase (CPOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coproporphyrinogen Oxidase (CPOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coproporphyrinogen Oxidase (CPOX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coproporphyrinogen Oxidase (CPOX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coproporphyrinogen Oxidase (CPOX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coproporphyrinogen Oxidase (CPOX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coproporphyrinogen Oxidase (CPOX) ELISA Kit Customized Service Offer
  1. "Coproporphyrinogen oxidase: gene organization and description of a mutation leading to exon 6 skipping."Hum. Mol. Genet. 3:1325-1330(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning, sequencing and expression of cDNA encoding human coproporphyrinogen oxidase."Biochim. Biophys. Acta 1183:547-549(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning, sequencing, and functional expression of a cDNA encoding human coproporphyrinogen oxidase."Proc. Natl. Acad. Sci. U.S.A. 91:3024-3028(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The long, but not the short, presequence of human coproporphyrinogen oxidase is essential for its import and sorting to mitochondria."Tohoku J. Exp. Med. 200:39-45(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Structural basis of hereditary coproporphyria."Proc. Natl. Acad. Sci. U.S.A. 102:14232-14237(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms."Hum. Mol. Genet. 3:477-480(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria."Hum. Mol. Genet. 3:1807-1810(1994) [PubMed] [Europe PMC] [Abstract]
  12. "A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria."Hum. Mol. Genet. 4:275-278(1995) [PubMed] [Europe PMC] [Abstract]
  13. "A novel missense mutation in exon 4 of the human coproporphyrinogen oxidase gene in two patients with hereditary coproporphyria."Hum. Genet. 99:199-201(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Three novel mutations in the coproporphyrinogen oxidase gene."Hum. Mutat. 9:78-80(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Hereditary coproporphyria: exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene."Hum. Mutat. 10:196-200(1997) [PubMed] [Europe PMC] [Abstract]
  16. "Systematic analysis of coproporphyrinogen oxidase gene defects in hereditary coproporphyria and mutation update."Hum. Mutat. 13:44-53(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria."J. Hum. Genet. 47:407-412(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Biochemical and genetic characterization of four cases of hereditary coproporphyria in Spain."Mol. Genet. Metab. 85:160-163(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient."Br. J. Haematol. 132:237-243(2006) [PubMed] [Europe PMC] [Abstract]
  20. ErratumBr. J. Haematol. 132:662-662(2006)