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Vpr Binding Protein (VPRBP)

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DCAF1; VprBP; RIP; DDB1 And CUL4 Associated Factor 1; HIV-1 Vpr-binding protein; Serine/threonine-protein kinase VPRBP

Vpr Binding Protein (VPRBP)
CCC G675
HGNC 30911
MGI 2445220
PubMed 18332868
RGD 1305176
UniProt Q9Y4B6
Wiki VPRBP
Vpr Binding Protein belongs to the VPRBP/DCAF1 family. Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the substrate recognition module within this complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vpr Binding Protein (VPRBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vpr Binding Protein (VPRBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vpr Binding Protein (VPRBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vpr Binding Protein (VPRBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vpr Binding Protein (VPRBP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vpr Binding Protein (VPRBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vpr Binding Protein (VPRBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vpr Binding Protein (VPRBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vpr Binding Protein (VPRBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vpr Binding Protein (VPRBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Vpr Binding Protein (VPRBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Vpr Binding Protein (VPRBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Vpr Binding Protein (VPRBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Vpr Binding Protein (VPRBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Vpr Binding Protein (VPRBP) ELISA Kit Customized Service Offer
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